The Yi laboratory is interested in the research of pancreatic beta cells in Type 1 and Type 2 diabetes. The laboratory uses multidisciplinary approach to study pancreatic beta cell regeneration, function, stress and protection against autoimmune destruction in Type 1 Diabetes. Our goal is to discover and study novel therapeutic targets, and improve the treatment of both Type 1 and Type 2 diabetes.
Pancreatic Beta Cell Biology
- The mechanism of pancreatic beta cell replication.
- The mechanism of pancreatic beta cell neogenesis from pancreatic duct cells.
- Genetic protection of pancreatic beta cells against autoimmune destruction in Type 1 Diabetes.
- Genome-wide CRISPR screens to study various questions in beta cell biology.
Peng Yi, Ph.D.
Dr. Peng Yi is originally from Shandong, China, graduated from the University of Science and Technology of China. He was trained by Dr. Eric Olson and received his Ph.D. degree in UT Southwestern Medical Center. He then worked in Dr. Doug Melton’s lab in Harvard University as a postdoc fellow. In 2013, Dr. Yi become an Assistant Investigator in Joslin Diabetes Center. Currently he is also the director of Joslin Diabetes Center CRISPR screen core laboratory.