Pancreas Islet

Yi Laboratory

Learn about our interests in pancreatic beta-cell proliferation, regeneration, beta-cell protection against autoimmune destruction and more.


Principal Investigator

Peng Yi, Ph.D.


Peng Yi, Ph.D.

scientists in lab

The Yi laboratory is interested in the research of pancreatic beta cells in Type 1 and Type 2 diabetes. The laboratory uses multidisciplinary approach to study pancreatic beta cell regeneration, function, stress and protection against autoimmune destruction in Type 1 Diabetes. Our goal is to discover and study novel therapeutic targets, and improve the treatment of both Type 1 and Type 2 diabetes.

Meet our team



The Mechanism of Pancreatic Beta Cell Replication

We are interested in studying gene networks and signaling pathways that control pancreatic beta cell replication. The laboratory set up an acute insulin resistance mouse model by infusion of an insulin receptor antagonist, S961, which induces dramatic and specific pancreatic beta-cell replication.

Learn about our research

What's Happening

Protecting beta cells against type 1 diabetes


See Our Latest News

Blood glucose levels after beta cell replacement
Stephan Kissler, PhD and Peng Yi, PhD at Joslin Diabetes Center
Microscopy image of a pancreas from a diabetic mouse